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- Lead Select Per Oral: Discovery Kit Price: €699
- Availability: In stock.
Do You Want To Know The Relative Bioavailability Of Your Compound?
The Early BirdA potential new drug candidate needs to have a high degree of oral bioavailability. In other words, it should be readily available to the body after it’s been administered orally. Understanding the relative bioavailability of your compound at an early stage is critical. The number of poorly soluble candidates coming out of discovery is increasing all the time. Knowing this information early on can help you avoid selecting badly-behaved compounds. This knowledge can save you a huge amount of time and money in the long-term.
Finding The Right Vehicle
Ignoring the issue of insolubility could be dangerous. But finding the right oral dosing vehicle for a poorly soluble compound can be difficult. It’s a process complicated by many different factors:
- Lack of uniform vehicles
- Scarce amounts of the compound
- Insufficient time for vehicle optimization
If you could take insolubility out of the equation by using a well-defined standard vehicle, you’d be able to:
- Make a back-to-back comparison of your lead candidates when delivered orally
- Understand how solubilization influences oral bioavailability
- Make more informed decisions about the selection of your lead candidate by understanding its performance without the interference of crystallization
Avoid Precipitation
The Lead Select Per Oral: Discovery Kit is designed to enable the rapid testing of research compounds in a solubilized state. This allows you to explore the performance rapidly after first in animal oral dosing. It is suitable for a wide variety of poorly soluble research compounds.
The vials of solubilization vehicle contain a clear liquid containing a clever combination of a co-solvent mixture and solubilizer that dissolves a broad range of poorly soluble compounds.
The solubilizer in the product uses similar components to those found within the digestive tract of animals and forms sub micron particles upon contact with water. This carefully selected solubilizer aids the absorption of lipophilic components of the diet from the digestive tract of mammals.
Upon contact with water, microscopic structures are formed that keep the poorly soluble compounds dissolved. The resultant mixture can be diluted with water prior to administration via gavage.
The particles are so small that they appear clear even after dilution. This means that you can see if your compound crashes out after contact with water.
How LSPO Can Work For You
The LSPO: Discovery Kit is a standardized dosing vehicle for oral use. It’s been developed to give you a clear impression of the bioavailability profile of your compounds in single dosing studies.
It works through simple visual inspection. One quick look will tell you if the dosing vehicle has been successful in dissolving your compound. The LSPO: Discovery Kit is extremely simple to use; each kit comes complete with everything you need to start testing immediately. Your drug-loaded vehicles can be obtained in as little as 15 minutes. This kit is:
- Designed to dissolve a wide range of poorly soluble compounds
- A transparent dosing vehicle before and after dilution with water
- Suitable for use across many different species
When you’re starting to assess a lead candidate, poor solubility can really cloud your vision. By enabling you to see what the relative bioavailability of your compound is like when delivered orally, this kit will give you vital clarity. For superior oral dosing of your compound, get an LSPO: Discovery Kit into your lab today.
To find out how simple it is to use an LSPO: Discovery Kit click here
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