Increase The Solubility Of A Poorly Soluble Drug
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- Liposome Solubilizer 5mL Online Price: €99
- Availability: In stock.
- Liposome Solubilizer 100mL Online Price: €999
- Availability: In stock.
Solubilize Insoluble Compounds In A Flash!
Volume of Liposome Solubilizer | Amount of Drug required to test Solubilization | Amount of Drug required for Complete Loading | Recommended Use |
5mL | Ca 1 to 2mg | 10mg | Identify if Liposomes can solubilize your compound in vitro |
100mL | Ca 1 to 2mg | 200mg | Establish if Liposomes are suitable solubilizers intravenously with Pre-Clinical in vivo tests |
Why Is Solubilization So Important?
If you have a poorly soluble compound intended for intravenous administration, you must understand how it will perform after injection. You need a solubilizer that not only dissolves your compound but also keeps it in solution. If it precipitates out after injection this could result in the physical blockage of capillaries (emboli). Worse still, promising activity could be missed because the drug is not free to act. Unfortunately, only a few existing solubilization techniques are suitable for intravenous administration. Many solubilizers are poorly tolerated in Pre-Clinical species. Solubilizing an insoluble drug is no easy task.
How Liposomes Can Help
Historically, liposomes have mostly been used for targeting water soluble compounds. It’s notoriously difficult to load in poorly soluble drugs with conventional approaches, so their role as a well-tolerated solubilizer has largely been overlooked. But liposomes can be good solubilizers because they can help prevent drug precipitation. Also, unlike Cremophor for example, drug-loaded liposomes can be used in Pre-Clinical models which are intolerant to such surfactants.
Phares & Liposomes
Phares has worked with Liposomes since the 1980’s when we developed the first and foremost technique for large scale liposome production. In the 1990’s, we began to explore how liposomes could be used as an effective solubilizer. At the start of the new millennium, we made a significant breakthrough when we discovered that optically clear liposomes with well-defined particle size are highly effective solubilizers of insoluble compounds. Phares has spent the past decade refining different techniques of loading poorly soluble compounds into these carriers. Put simply: no other company in the industry understands liposomes as well as we do.
Previously, you would have had to spend more than 30,000 euros and taken several weeks to test whether liposomes would even be suitable for solubilizing your compounds. Well the exciting news is that Phares has elected to make our 20+ years of liposome know-how available to you! And, amazingly, you can import this state-of-the-art technology into your lab for less than 100 euros.
Introducing Phares Liposome Solubilizer
Liposome Solubilizer is a remarkable product. This sterile dispersion is made up of nano-sized lipid particles that keep poorly soluble drugs in solution. These particles are so small that the dispersion appears clear and transparent when held up to light. Similar lipids are found naturally in the blood and keep poorly soluble compounds safely dissolved in the body without precipitation. All you need to do is make a solution of your compound and add it to Liposome Solubilizer! This product offers so many commercial benefits in addition to the technical ones:
*Great Usability*
- Different volumes of drug solubilized in liposomes can be produced easily in a matter of minutes
- There’s no need for expensive specialist equipment. The liposomes are always the same so they can be used as a standard solubilizing vehicle for a range of poorly soluble compounds
*Premium Quality*
- The Liposomes are produced sterile in Switzerland under a standardized protocol. We use a specifically designed parenteral grade lipid which conforms to strict specifications
- Every vial is Quality Controlled, assured prior to release and shipped with a Certificate of Analysis
*High Innovation*
- Liposome Solubilizer boasts high solubilization capacity. The small liposomes fall apart upon injection so targeting is avoided and drug is easily released after injection
- Because the liposomes are clear, you can tell from simple visual inspection after loading if your drug has been solubilized successfully
Meeting Your Requirements
Liposome Solubilizer is the most simple and cost effective way to produce drug solubilized liposomes. You can buy a small amount (5mL) to explore the solubilization of up to at least 5 compounds. A larger vial (100mL) is available for intravenous Pre-Clinical testing. Even bigger volumes are available for later stage Pre-Clinical testing. Please contact us for more information.
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