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- SIF Powder 56g Price: €599
- Availability: In stock.
- SIF Powder 560g Price: €3999
- Availability: In stock.
Good News If You Prepare FeSSIF And/Or FaSSIF In Your Lab!
The Growing Importance Of Instant Biorelevant Media
The use of Fed State (FeSSIF) and Fasted State (FaSSIF) simulated intestinal fluid has been growing since its conception by Professor Jennifer Dressman.
These biorelevant media are essential tools in helping to understand the behaviour of your compound, both alone and as part of a formulation. This is due to the increasing complexity of molecules caused by the shift in targets and the increase in lipophilicity.
As well as being used for dissolution testing, Professor Jennifer Dressman's biorelevant FeSSIF and FaSSIF are also now used for solubility testing, and even miniaturized solubility testing. This information can:
- Provide an insight into its potential food effect behaviour
- Minimize animal testing by helping establish an in vitro in vivo relationship (IVIVR)
- Indicate how your compound should be delivered
Instant biorelevant media could play a vital role in helping you piece your insolubility puzzle together, particularly for poorly soluble compounds.
Don’t Be Sent Down The Wrong Path
It's critical that the biorelevant media performs consistently, above all when determining solubility. If you're testing the solubility of a series of leads, you cannot afford for the differences in solubility to be due to variations in the media being used. Differences in composition and quality can adversely affect your results. With the wrong findings, you could easily be sent down the wrong path. This is why you must have precision within each batch and also between different batches of media.
Until Now…
Both FeSSIF and FaSSIF have had to be prepared from scratch using a conventional method that is cumbersome, costly and time-consuming. This method:
- Requires numerous separate ingredients which all need to be sourced in
- Can be difficult to transfer between analytical laboratories
- Uses a chlorinated solvent
- Is awkward to produce if volumes exceed even a few litres
Furthermore, if it’s to be stored for more than a day the media has to be sterilized to avoid bug spoilage. And if it’s for immediate use, it has to be produced fresh every time. This all amounts to a very tricky process. No product combining speed, simplicity and reproducibility has been commercially available. Until now, that is.
Make Life Easier
Wouldn’t it be great if you could prepare simulated intestinal media in a simple, speedy way? Imagine if you could produce and use FeSSIF and FaSSIF on the same day - immediately after preparation? You’d suffer no wastage and have no need for long-term storage. You’d save precious lab time and money.
This might sound as though it belongs somewhere in the future, but we can assure you it doesn’t. Through ePhares.com, it’s available right now.
Phares SIF Powder: The Answer To A QC Analyst’s Prayers
In response to our clients’ requests, Phares has spent considerable lab time developing a special product for QC Analysts or Researchers who want instant biorelevant media. Phares SIF Powder is our answer.
The benefits of using our SIF Powder are huge:
- Prepare highly reproducible FeSSIF and FaSSIF from the same powder - our unique production method ensures that the homogeneity of the SIF powder is excellent. There is no variability between the same (inter) and different (intra) batches
- No wastage or expensive sterile filtration needed – produce the fluid as and when you need it
- Saves precious time and money because the powder dissolves instantly
- Rigorous QC - the input materials are stringently controlled. Every batch is carefully checked before release
- Volume flexibility - both large volumes of 100 liters for dissolution testing or small volumes of 1 mL for solubility testing can be produced quickly and simply
“Simple and straightforward to use.” Leslie Kurichiyil, Project Leader, Pharmaceutical Development Analytics, Mepha, Switzerland
Buy SIF Powder Now!
Producing instant biorelevant media through conventional methods can absorb a lot of time and a lot of money. Phares SIF Powder can save you that time and money and help you get the results you need fast. You can be producing a superior simulated intestinal fluid in your own lab in less than 5 minutes! Our standard bottle of SIF Powder (56g) will make up 5 L of FeSSIF or 25 L FaSSIF and is exclusively available through ePhares.com. Buy it today!
To find out how simple it is to use Phares SIF Powder click here
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