Inject the Compound dissolved in liquid A (transfer medium) into liquid B (lipid dispersion)
Gently swirl until the transient turbidity disappears
After about 30 seconds, the Compound-loaded dispersion clarifies and is ready for administration
Click on image to enlarge
- Lead Select Intravenous: Discovery Kit Price: €849
- Availability: In stock.
How To Use The Lead Select Intravenous: Discovery Kit
What’s In It?
The LSIV: Discovery Kit is a ready-to-use kit containing:
- Liquid A (Transfer Medium (Enhancer in NMP)): The vial (1 x 10 mL) contains a sterile solvent mixture containing phospholipid
- Liquid B (Lipid Dispersion): The vials (6 x 4.5 mL) contain a sterile dispersion made up of nano-sized lipid particles
- 6 x empty vials (6 mL) with screw caps
- 12 x disposable syringes (1 mL) with needles
- 6 x disposable sterile filters
How Do You Use It?
You simply dissolve your drug in the Liquid A (Transfer Medium) in the empty vial provided. If the compound dissolves, add 1 part of this clear Liquid A to 9 parts of the Liquid B (Lipid Dispersion). If the resultant solution is visually clear, you know you have solubilized your compound. It really is as simple as that.
Typically, upon addition of the drug in Transfer Medium to the
Lipid Dispersion, the drug immediately precipitates but then instantly
solubilizes into the submicron-sized lipid structures.
How Do You Store It?
Liquid A (Transfer Medium) should be stored at room temperature and Liquid B (Lipid Dispersion) should be kept at 2-8°C and protected from light.
Downloadable PDF User & Dosing Guides
To download our PDF User Guide for Lead Select Intravenous: Discovery Kit click here
To download our PDF Dosing Guide for Lead Select Intravenous: Discovery Kit click here
FAQs
Q. Is the LSIV: Discovery Kit simple to use?
A. Yes. It is prepared as a ready-to-use kit with all the components you will need provided in one pack. Each kit has an easy to follow user guide (available for download here and emailed upon order) and full support material (dosing information, MSDS, Certificate of Analysis).
Q. Is the LSIV: Discovery Kit suitable for poorly soluble small molecule drugs?
A. Yes. This product has in fact been designed for poorly soluble small molecule drugs.
Q. What happens when the formulation has been diluted with infusion media or components in the blood?
A. The drug remains dissolved so precipitation is prevented.
Q. How much product does an LSIV: Discovery Kit contain?
A. Each LSIV: Discovery Kit contains 6 vials each containing 4.5 mL of Lipid Dispersion and 10 mL of Transfer Medium (Enhancer in NMP).
Q. What is the final recommended drug concentration?
A. The recommended drug concentration in the final dispersion is 2 mg/ml.
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