How To Solubilize An Insoluble Drug With Liposomes
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- Liposome Solubilizer 5mL Online Price: €99
- Availability: In stock.
- Liposome Solubilizer 100mL Online Price: €999
- Availability: In stock.
How Liposome Solubilizer can increase the solubility of Poorly Soluble Compounds
This product is designed for use in your labs to:
1) Rapidly and cost effectively establish if it can solubilize your poorly soluble compound in vitro
2) If successful, it can be used for Pre-Clinical research to administer your insoluble drug intravenously.
How To Solubilize Your Insoluble Compound With Phares Liposome Solubilizer
Phares Liposome Solubilizer can solubilize your poorly soluble compounds ready for intravenous administration in just minutes via a very easy 2-step process:
1) Dissolve your compound in an organic solvent of your choice
2) Add 1 part of this drug in solvent to 9 parts of Liposome Solubilizer
Download our Liposome Solubilizer User Guide for more detailed usage instructions: here.
Designed For Insolubles
Liposome Solubilizer uses a specifically developed composition formulated to solubilize poorly soluble drugs effectively and safely for intravenous administration. The Liposomes are not intended to encapsulate or target water soluble compounds because they are specifically designed to disintegrate rapidly upon injection to release the drug.
Which Compound Properties Are Suitable?
Compounds not fully soluble in water at a concentration of about 2 mg/ml are best suited to Phares Liposomes. The compound also needs a solubility of at least about 20 mg/ml in a water miscible organic solvent.
How Much Compound Is Needed For Testing?
If inspection for precipitation is carried out visually, about 1 to 2 mg of drug substance in a volume of Liposome Solubilizer of about 0.5 ml is typically ok. If you use a separation technique or microscope, much less than 1 mg is feasible.
Designed For Research
The simplicity of testing and cost effectiveness of Phares Liposome Solubilizer means that the solubilizing potential of Liposomes for compounds even in discovery and early research can now be explored with just a few mgs (including first in vivo Pre-Clinical tests).
Phares Liposome Solubilizer should be stored in the refrigerator and protected from light. Before opening the vial, let the vial warm up to room temperature. The re-test date, stated on the accompanying Certificate of Analysis, is 6 months. Please note, this product should not be frozen.
Further Tips For Best Results
At Phares, we are continually researching how to improve the delivery of poorly soluble pharmaceuticals. Here are some further tips to help you obtain the best results:
*Filter before administration*
Liposome Solubilizer should be filtered aseptically (drug free control as well as drug loaded) before intravenous administration through a sterile filter (either PVDF or PTFE with 0.45 µm pore size). This conveniently removes microbes or small amounts of unsolubilized drug. Please note that when using filters, as with all injectables, adsorption of your compound to the filter should be checked because some compounds may bind to the filters.
*Check drug content*
As with all formulations/vehicles, if you want to check the drug content by HPLC or UV, correct for background interference using the Liposome Solubilizer without drug, typically at wavelengths between 200 and 280 nm.
*Re-using opened vials*
Phares Liposome Solubilizer does not contain anti-microbial preservatives. Therefore, opened containers should not be re-used to avoid microbial contamination.
*Shake*
Shake well before use. Occasionally, redispersible aggregates may appear in the Liposome Solubilizer. These can easily be removed by either shaking or filtration before administration.
*Storage after adding drug*
As with any solubilized systems, the drug in Liposome Solubilizer should generally be used within one hour unless the chemical and physical stability of the drug in the Liposome Solubilizer has been tested.
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