Prepare the selected buffer
Add the appropriate amount of SIF Powder to the selected buffer
Powder rapidly dissolves within one minute to produce a clear dispersion which is ready for immediate use
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- SIF Powder 56g Price: €599
- Availability: In stock.
- SIF Powder 560g Price: €3999
- Availability: In stock.
How To Use SIF Powder To Produce Instant Biorelevant Media
What's In It?
SIF Powder is a complex of highly pure Sodium Taurocholate and diacylphospholipid.
How Do You Use It?
Simply add SIF Powder to the desired buffer and the free-flowing powder will produce well defined FeSSIF and FaSSIF containing mixed micelles in minutes. No heating, no evaporation, no waiting around. It really is that easy.
How Do You Store It?
SIF Powder should be stored at 2-8°C and protected from light and humidity. Before opening the bottle, equilibrate to room temperature.
Downloadable PDF User Guide
To download our PDF User Guide for SIF Powder click here
FAQs
Q. Can you prepare both FaSSIF and FeSSIF media with SIF Powder?
A. Yes. Phares SIF Powder enables you to produce FaSSIF & FeSSIF fluids with ease: just prepare your buffer solution, add the appropriate amount of SIF powder, stir briefly and you are ready to start dissolution testing.
Q. What’s the difference between FeSSIF & FaSSIF?
A. FeSSIF is simulated intestinal fluid in a Fed state (after intake of food). FaSSIF is simulated intestinal fluid in a Fasted state (before intake of food). Both media contain mixed micelles which are natural solubilizers that are secreted to absorb fats and other lipophilic components e.g. lipophilic drugs in the intestines. The main difference between FeSSIF and FaSSIF is that they contain different concentrations of these natural solubilizers. FeSSIF contains a four fold higher concentration of these natural solubilizers than FaSSIF. Also the pH values of these media are different.
Q. When using SIF Powder does the resulting dissolution media compare to the Dressman formulation?
A. Yes, the buffer systems to be used in combination with Phares SIF Powder are based on the ionic compositions of the traditional FeSSIF & FaSSIF dissolution media comprising mixed micelles of taurocholate and phospholipid as described by Professor Jennifer Dressman and Margareth Marques. See our User Guide (above) for more info.
Q. Is SIF Powder reproducible?
A. Yes.
Q. What is the expiry date for a batch?
A. 18 months for an unopened bottle.
Q. Can I use another buffer?
A. Yes, but we recommend using Professor Jennifer Dressman's standard buffer.
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