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- SIF Powder 5.6g Price: €99
- Availability: In stock.
- SIF Powder 56g Price: €499
- Availability: In stock.
- SIF Powder 560g Price: €2999
- Availability: In stock.
How To Prepare FeSSIF + FaSSIF from Phares SIF Powder
Preparing FeSSIF or FaSSIF from SIF Powder is a very easy 2-step process:
1) Prepare the buffer
2) Add the SIF Powder
Such a simple method enables you to freshly produce any volume of media required in just minutes. One 56g bottle of SIF Powder produces 5 L of FeSSIF or 25 L of FaSSIF.
Download our SIF Powder Preparation Protocol to find out more: click here
How To Store SIF Powder
SIF Powder should be stored at between 2-8°C and protected from light and humidity. Before opening the bottle, equilibrate to room temperature. The expiry date, stated on the accompanying Certificate of Analysis, is 18 months.
Tips For Getting The Best Results From Your FeSSIF/FaSSIF Media
At Phares, we are continually conducting research into the field of biorelevant media for industrial application. It is part of our customer care policy to update our customers with this information so you can benefit from our latest findings.
*Use HPLC as your analytical tool*
HPLC or specialist UV equipment is recommended as an analytical tool for more accurate quantitative drug analysis in the presence of FeSSIF and FaSSIF media to eliminate possible UV interference.
*Make FeSSIF/FaSSIF freshly to reduce the risk of microbial spoilage or physicochemical changes*
As FeSSIF and FaSSIF are so quick and easy to prepare using SIF Powder you can make it freshly, eliminating the need to store the media.
Tips For Preparing FeSSIF/FaSSIF Media With Reproducible Physical Properties
*Equilibrate FaSSIF media to obtain a stable particle size*
We recommend in our Preparation Protocol equilibrating this media for 2 hours after preparation before use to obtain a stable particle size.
*Avoid storing FaSSIF media in the refrigerator*
We suggest avoiding storage in the refrigerator as this can change the particle size of FaSSIF.
To read these preparation tips in greater
How Are FeSSIF + FaSSIF Used In R&D?
FeSSIF and FaSSIF are used to test the solubility and dissolution rate of a drug in research and development. These two parameters influence the degree of absorption of an orally administered drug. There is no need to modify existing solubility or dissolution equipment for these tests.
- Compare the solubility of your potential drug candidates in lead optimization
- Measure the equilibrium solubility of your pre-clinical candidate during pre-formulation
- Explore how your drug dissolved in biorelevant media behaves in CaCO2 cells
The main applications for dissolution testing are:
- Used to discriminate between and rank different formulations (such as solid dispersions) containing the same drug
- Test the dissolution of your drug using either conventional USP or miniaturized dissolution equipment (e.g. Sirius Analytical equipment)
- Test the dissolution and precipitation behaviour of your drug after switching from SGF to FeSSIF or FaSSIF
- Identify if a biowaver is possible or bioequivalence studies are required for your generic insoluble compound
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